What role does CYP1A2 play in longevity?

CYP1A2 encodes a cytochrome P450 enzyme primarily responsible for metabolizing caffeine and certain drugs. In longevity research, it is not a major player. Some studies suggest that genetic variants (e.g., rs762551) affect caffeine clearance and may modestly influence cardiovascular risk or coffee tolerance. However, a direct, reproducible link to lifespan is lacking. The evidence is mostly mechanistic and based on association studies with small effect sizes. MyBody-X can detect CYP1A2 variants, but the clinical relevance for longevity is low. While the information may help personalize caffeine intake, it should not be marketed as a longevity gene. Consumers should be cautious of overblown claims. No robust human data support a meaningful role in extending lifespan.