How are CYP1A2 and Langlebigkeit related?

The relationship between CYP1A2 and longevity is indirect and not well established. CYP1A2 is a cytochrome P450 enzyme involved in metabolizing drugs, environmental toxins, and caffeine. Some studies suggest that certain CYP1A2 variants may modulate risk for cancer or cardiovascular disease – factors that can influence lifespan. However, effect sizes are small and highly dependent on lifestyle (e.g., caffeine intake, smoking). Direct evidence for an impact on longevity itself is lacking. Consumer DNA tests often overstate such links. Evidence grade: unclear/mixed. Safety note: CYP1A2 variants can affect drug metabolism; any dietary or medication changes should be discussed with a physician.