Is VDR useful for Fruchtbarkeit?

The utility of VDR (vitamin D receptor) genetic testing for fertility is not well supported by current evidence. Vitamin D is involved in reproductive physiology, including hormone regulation, ovarian function, and sperm quality. However, the impact of common VDR polymorphisms (e.g., rs2228570, rs1544410) on fertility outcomes is inconsistent across studies and generally weak. Most research is observational, with small effect sizes and limited replication. Therefore, a direct clinical benefit from VDR genotyping for fertility is unlikely. Consumer DNA tests often overstate such associations. A more evidence-based approach is to measure serum 25-hydroxyvitamin D levels and correct deficiencies if present. Genetic testing for VDR should not replace standard fertility diagnostics or medical advice. The evidence level is best described as 'mechanistic' or 'unclear' due to lack of robust human data.