What role does Selen play in Wechseljahre?

Selenium is an essential trace mineral that functions as a component of selenoproteins such as glutathione peroxidase (GPX), which protect cells from oxidative damage. During menopause, estrogen levels decline, reducing the body's natural antioxidant capacity and increasing oxidative stress. Selenium may theoretically help counteract this stress and support thyroid function, which is also affected by hormonal changes. However, the evidence for selenium supplementation specifically for menopause symptoms is limited. No large-scale clinical trials confirm clear benefits, and excess selenium can be toxic (selenosis). Direct-to-consumer DNA tests may report variants in the GPX1 gene, but their clinical relevance is uncertain. Supplementation based solely on genetic testing is not recommended. Instead, selenium should be obtained from dietary sources like Brazil nuts, fish, and eggs. In summary, selenium plays a plausible but unproven role in menopause; any supplementation should be guided by a healthcare professional after assessing actual deficiency.