What role does COMT play in longevity?

COMT (catechol-O-methyltransferase) degrades dopamine and other catecholamines. The well-studied rs4680 (Val158Met) variant alters enzyme activity: the Met allele reduces activity, leading to higher prefrontal dopamine levels. This has been linked to cognitive performance, stress resilience, and emotional regulation—traits that may influence healthy aging. However, direct evidence for a role in longevity is limited. Genome-wide association studies (GWAS) on lifespan do not highlight COMT as a major locus; any effects are small and context-dependent (e.g., sex, environment). Consumer DNA tests like MyBody-X can report your COMT genotype, but using it to predict your personal longevity is not scientifically robust. The test is for informational use only, not for medical diagnosis or life expectancy claims. Lifestyle factors (diet, exercise, sleep) have far greater impact. Safety note: Do not make health decisions based solely on this gene.