CRP (C-reactive protein) is a non-specific marker of inflammation that can be elevated in many conditions—infections, autoimmune diseases, tissue damage, and even stress. For allergy diagnosis or management, CRP is not useful. Allergies are mediated by specific IgE antibodies and are diagnosed through targeted tests such as skin prick tests or specific IgE blood tests. While CRP may rise during severe allergic reactions (e.g., anaphylaxis), it lacks the specificity and sensitivity to serve as an allergy marker. Using CRP as an 'inflammation test' in an allergy context is misleading and may cause unnecessary worry or false reassurance. Clinical guidelines do not recommend CRP for allergy assessment. If an allergy is suspected, consult an allergist for proper evaluation. Evidence: clinical practice. Sources: no specific PMIDs provided in the context.
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