How are Leaky Gut Test and longevity related?

The relationship between 'leaky gut' tests and longevity is not scientifically established. 'Leaky gut' refers to a hypothesized increase in intestinal permeability. Commercial tests (e.g., stool zonulin) lack clinical validation and are not approved for diagnosis. While some research links gut barrier dysfunction to chronic inflammation and aging (inflammaging), the evidence is mostly mechanistic or observational, not causal for human lifespan. Most direct-to-consumer leaky gut tests are marketing-driven, with small effect sizes and no proven ability to predict or extend longevity. Even if permeability is altered, it does not reliably indicate accelerated aging or mortality risk. Proven longevity factors—diet quality, exercise, sleep, stress reduction—are far more impactful. Caveat: Do not use these tests for medical decisions. If you have digestive symptoms, see a gastroenterologist.