How are IgG and Wechseljahre related?

The direct relationship between IgG (immunoglobulin G) and menopause (Wechseljahre) is not well established in scientific literature. IgG is an antibody involved in immune memory. During menopause, declining estrogen levels can modulate immune function, and some studies report minor changes in IgG subclasses, but these are inconsistent and not clinically meaningful. IgG food sensitivity tests, often marketed for various symptoms, lack robust evidence for diagnosing or managing menopause-related issues. The evidence is primarily mechanistic or based on small observational studies. Therefore, using IgG levels to guide menopause treatment is not supported. For managing menopausal symptoms, evidence-based approaches like hormone therapy, lifestyle adjustments, and symptom-specific treatments are recommended.