Ferritin is a protein that stores iron. Low ferritin levels can indicate iron deficiency, a common cause of fatigue – especially in women with heavy menstruation, vegetarians, or those with chronic blood loss. Studies show that iron supplementation in confirmed deficiency significantly reduces fatigue. However, ferritin is not a direct 'anti-fatigue' supplement. High ferritin (e.g., from inflammation or hemochromatosis) is not beneficial and may be harmful. A blood test ordered by a doctor is necessary to assess individual needs. Consumer self-tests without clinical interpretation risk misguidance. Evidence: human-strong for iron deficiency and fatigue link. Caveat: ferritin alone is insufficient; transferrin saturation and CRP should also be measured.
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