CRP (C-reactive protein) is a well-established marker of inflammation. Epidemiological studies consistently link chronically elevated CRP levels to insulin resistance and type 2 diabetes, but the causal relationship is complex and not fully understood. Obesity, physical inactivity, and subclinical inflammation drive both CRP and blood sugar increases. The CRP gene variant rs1205, sometimes included in direct-to-consumer DNA tests, has uncertain clinical significance: it may modestly influence baseline CRP, but a direct causal effect on blood sugar or stress-induced inflammation is not proven. Evidence for personalized dietary recommendations based on such single SNPs is weak – large randomized controlled trials are lacking. In summary, CRP and blood sugar are connected through inflammatory pathways, but a single gene test does not provide actionable guidance. A holistic lifestyle approach (diet, exercise, weight management) remains the evidence-based strategy for regulating both markers.
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