How are IgE and longevity related?

The relationship between IgE and longevity is not well established. IgE is primarily involved in allergic responses and defense against parasites. Some studies in centenarians report lower IgE levels, suggesting reduced allergic burden or altered immune regulation. Conversely, moderate IgE elevations may reflect a robust immune system. The provided context lacks direct evidence linking IgE to longevity. Therefore, the evidence is mechanistic/unclear. No causal association can be drawn. Lifestyle, chronic inflammation, and longevity-associated genes (e.g., FOXO3) are likely more relevant. Measuring IgE alone is not a validated longevity biomarker.