What do studies say about MTHFR Männer?

Studies on MTHFR variants in men are largely observational and inconclusive. The MTHFR gene encodes an enzyme in folate metabolism; the common C677T variant can elevate homocysteine levels. Some meta-analyses suggest modest associations with male infertility, erectile dysfunction, and cardiovascular risk, but effect sizes are small and depend on folate status. Importantly, a single genetic test cannot diagnose any condition. Evidence is human-observational (moderate) – no RCTs exist for MTHFR-based interventions in men. Consumer DNA tests like MyBody-X provide risk estimates, not clinical directives. Men with MTHFR variants should ensure adequate folate intake, but supplementation with folic acid or methylfolate should be discussed with a doctor, as excess can be harmful. Overall, the predictive value for individuals is limited; lifestyle and other genetic factors are more impactful.