How are FOXO3 and longevity related?

FOXO3 is a transcription factor central to longevity research. It regulates stress resistance, autophagy, and insulin/IGF-1 signaling. Specific SNPs (e.g., rs2802292) have been associated with human longevity in multiple GWAS and cohort studies, particularly in centenarians. However, effect sizes are modest and population-specific. The provided context does not contain direct information on FOXO3, so this answer reflects general scientific knowledge rather than the given materials. Consumer DNA tests may report FOXO3 variants, but their predictive value for individual lifespan is low. Longevity is polygenic and heavily influenced by lifestyle, diet, and environment. Evidence: unclear from context. Caveat: Not a diagnostic or predictive tool.