Evidence check: CLOCK in the context of Langlebigkeit

CLOCK (Circadian Locomotor Output Cycles Kaput) is a core circadian gene. Variants have been linked to sleep timing, metabolic health, and cardiovascular risk in GWAS and observational studies – all factors that can indirectly affect longevity. However, direct evidence that CLOCK polymorphisms causally determine human lifespan is weak. Most findings come from animal models or candidate-gene studies with small effect sizes and inconsistent replication. Consumer DNA tests for CLOCK provide no actionable or clinically validated longevity prediction. The associations are context-dependent (e.g., light exposure, diet) and not robust enough for personalized recommendations. Therefore, while circadian biology is important for healthspan, a single CLOCK test result should not be used to guide anti-aging interventions. Evidence: human-moderate.