What to watch with hsCRP and weight loss?

HsCRP (high-sensitivity C-reactive protein) is a general inflammation marker. Weight loss can lower hsCRP because adipose tissue releases pro-inflammatory cytokines. However, this reduction is not genotype-specific. Claims that a DNA-based diet can lower hsCRP are not supported by evidence. Effective strategies are general lifestyle changes: calorie restriction, increased physical activity, stress management. Caveat: elevated hsCRP (>2–3 mg/L) may indicate underlying inflammation, infection, or cardiovascular risk – medical workup is essential before starting any diet or supplement. Consumer DNA tests do not provide clinically actionable guidance for hsCRP reduction. Evidence for genotype-specific hsCRP lowering is weak (human-observational).