BDNF (Brain-Derived Neurotrophic Factor) is primarily known for its role in the nervous system, but it is also expressed in the skin and may be involved in wound healing, inflammation, and skin aging. Some consumer DNA tests analyze variants like rs6265 (Val66Met), which can affect BDNF secretion. However, the evidence linking BDNF variants directly to skin conditions (e.g., psoriasis, eczema) is mostly mechanistic and not clinically validated. Skin health is multifactorial, involving genetics, environment, and lifestyle. A single BDNF marker should not be used to guide skincare or supplementation. Focus on general skin health practices: sun protection, moisturizing, balanced diet. For specific skin issues, consult a dermatologist. Evidence: mechanistic/unclear.
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