Is tTG IgA useful for Allergie?

tTG IgA (tissue transglutaminase IgA) is a well-established biomarker for celiac disease, not for allergies. Celiac disease is an autoimmune condition triggered by gluten, whereas allergies (e.g., food allergies) are IgE-mediated reactions. tTG IgA has no proven utility in diagnosing or managing allergies. Confusion arises because both celiac disease and allergies can cause gastrointestinal symptoms. For allergies, specific IgE tests or skin prick tests are appropriate. Evidence for tTG IgA in celiac disease is strong (clinical guidelines), but for allergies it is absent. Caveat: A positive tTG IgA test should be confirmed by duodenal biopsy before starting a gluten-free diet. MyBody-X advises consulting an allergist for allergy concerns.