What role does ADH1B play in skin aging?

ADH1B encodes alcohol dehydrogenase, an enzyme that metabolizes ethanol in the liver. Certain variants (e.g., rs1229984) lead to faster alcohol clearance and are associated with altered alcoholism risk. A direct role in skin aging is not scientifically established. Indirectly, alcohol metabolism could affect skin via oxidative stress, inflammation, or dehydration, but evidence is weak and mechanistic. Consumer DNA tests often overstate the relevance of such genes for skin aging. UV protection, diet, and lifestyle are far more impactful. Evidence grade: mechanistic/unclear.