Is Folsäure useful for Wechseljahre?

Whether folic acid is useful during menopause is not straightforward. Folic acid (vitamin B9) is essential for DNA synthesis and homocysteine metabolism. Homocysteine levels often rise after menopause, which is a cardiovascular risk factor. Supplementation with folic acid (often with B12 and B6) can lower homocysteine, but evidence that it directly reduces menopausal symptoms like hot flashes or mood changes is weak. The typical dose is 400–800 µg daily; exceeding 1 mg may mask B12 deficiency. DNA tests for MTHFR variants are generally low-evidence for guiding supplementation; most people metabolize folic acid normally. Caveat: Folic acid is critical before and during early pregnancy, but for menopause the benefits are less clear. Evidence is mixed. Always consult a healthcare provider before high-dose supplementation.