FT4 (free thyroxine) is the active thyroid hormone and plays a key role in glucose metabolism. It stimulates hepatic gluconeogenesis, increases insulin resistance in peripheral tissues, and enhances intestinal glucose absorption. Consequently, hyperthyroidism (elevated FT4) often leads to higher blood glucose levels, while hypothyroidism (low FT4) tends to reduce glucose production and utilization. These relationships are well-established in endocrinology, though individual responses vary. FT4 does not act in isolation; diet, physical activity, stress, and other hormones modulate its effects. Therefore, abnormal FT4 values warrant medical evaluation, especially in individuals with diabetes or metabolic disorders. The evidence is human-strong, based on decades of clinical and physiological research. The provided context does not contain specific sources on FT4 and blood glucose.
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