Is FUT2 useful for sleep?

Is FUT2 useful for sleep? Based on current evidence, the answer is no. FUT2 (fucosyltransferase 2) determines secretor status and shapes gut microbiome composition. Through the gut–brain axis, a theoretical link to sleep exists, but direct clinical evidence is lacking. GWAS data for rs601338 (a common FUT2 variant) show associations with blood protein levels (ALPP/LAMP3), not sleep traits. Consumer DNA tests can report your FUT2 genotype, but interpreting it for sleep quality or disorders is speculative. The effect size is small and confounded by many lifestyle factors. For sleep issues, evidence-based approaches (sleep hygiene, stress reduction, medical evaluation) are far more relevant than genetic testing. In summary: FUT2 is not a validated sleep biomarker; the evidence is mechanistic and insufficient.