What role does HLA-DQ2 play in longevity?

The provided context contains no direct information on the role of HLA-DQ2 in longevity. HLA-DQ2 is a well-known risk allele for celiac disease, an autoimmune condition triggered by gluten. Untreated celiac disease can lead to chronic inflammation, malnutrition, and increased mortality, potentially shortening lifespan. However, with strict adherence to a gluten-free diet, this risk normalizes. There is no robust evidence that HLA-DQ2 directly affects longevity in healthy individuals without celiac disease. The evidence is best described as unclear or mechanistic – the link is indirect and not supported by longevity-specific studies. A genetic test for HLA-DQ2 alone does not predict lifespan; clinical markers such as inflammatory status or gut health are more actionable.