Vitamin D is a fat-soluble vitamin essential for bone health, immune function, and cell division. Sunlight exposure is the primary source, but in northern latitudes UVB radiation is insufficient during winter. MyBody-X offers a Vitamin D blood test (25-OH-D) and a DNA nutrition test that analyzes variants in the VDR gene (vitamin D receptor). These variants can influence how efficiently the body uses vitamin D. The evidence for measuring vitamin D levels in at-risk groups (e.g., elderly, dark-skinned individuals, chronically ill) is strong. However, the evidence for personalizing supplementation based solely on genetic variants is still limited. Most studies support maintaining a 25-OH-D level of at least 50 nmol/L for the general population, but genetically driven 'resistance' to vitamin D is rare. MyBody-X therefore recommends using the blood test as a primary tool and the genetic analysis as supplementary information. High-dose supplementation without medical supervision can cause hypercalcemia. Diet alone (fatty fish, eggs, mushrooms) typically covers only 10–20% of requirements. A holistic approach combining sun exposure, food, and targeted supplementation is best supported by evidence.
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