What role does HLA-DQ2 play in menopause?

HLA-DQ2 is primarily known for its strong association with celiac disease, an autoimmune condition triggered by gluten. It encodes a protein that presents gluten peptides to immune cells. There is no established or evidence-based role for HLA-DQ2 in menopause. Menopause is driven by hormonal changes (declining estrogen) and ovarian aging, not by HLA genotype. While some research explores HLA variants in premature ovarian insufficiency or autoimmune oophoritis, HLA-DQ2 specifically has not been linked to menopause timing or symptoms. Claims connecting HLA-DQ2 to menopause are not supported by current scientific literature. Consumer DNA tests suggesting such links should be viewed with caution, as they may overstate genetic influence.