Can HDL help with Langlebigkeit?

Whether HDL (high-density lipoprotein) contributes to longevity is scientifically nuanced. Epidemiological studies consistently show an inverse association between HDL cholesterol and cardiovascular events – people with higher HDL tend to live longer. However, randomized controlled trials that pharmacologically raise HDL (e.g., CETP inhibitors, niacin) have failed to demonstrate improved cardiovascular or all-cause mortality. Mendelian randomization studies further suggest that genetically elevated HDL is not causally protective against heart disease or overall death. Thus, HDL appears to be a marker of a healthy lifestyle (exercise, moderate diet) rather than a direct longevity agent. For lifespan extension, factors like inflammation, insulin sensitivity, and telomere length are likely more impactful. A single HDL measurement from a home test provides limited actionable insight for longevity. Evidence: mixed – strong observational data, but lack of causal confirmation.