Myths vs facts: Cardio Risk Check and menopause

Myths vs facts: Cardio Risk Check and menopause. Many direct-to-consumer tests claim to predict cardiovascular risk during menopause using genetic variants (e.g., rs1800629 in the TNF gene). Fact: Menopause increases CVD risk due to estrogen decline, but DNA tests only show a small genetic predisposition – they do not replace clinical markers like blood pressure, lipids, or inflammation. The association of rs1800629 with pulse pressure measurement (p = 8e-19) is robust, but the effect is small (beta = 0.29 mmHg) and not menopause-specific. A myth is that a 'good' genetic result protects against heart attack – in reality, lifestyle, diet, and hormonal status dominate. Another myth: a single biomarker (e.g., cortisol) is sufficient. Home tests measure only one time point and cannot diagnose. Bottom line: Genetic tests provide hints but not definitive risk assessment. Always consult a physician for menopausal symptoms and cardiovascular risk.