Myths vs facts: BDNF and skin aging

The BDNF variant rs6265 (Val66Met) is well-studied: it influences the secretion of brain-derived neurotrophic factor, which is crucial for neuronal plasticity and the response to physical activity. Carriers of the Met allele show reduced BDNF secretion in some studies and may benefit particularly from regular endurance exercise to support cognitive function. However, the effect is small and not deterministic – exercise is beneficial for everyone regardless of genotype. Direct-to-consumer DNA tests like MyBody-X can provide this hint, but they measure only a single SNP, not the full biological complexity. The evidence is based on observational and mechanistic studies, not on randomized controlled trials that prove genotype-specific exercise recommendations. Therefore, the predictive power is limited. A healthy lifestyle with adequate exercise, sleep, and nutrition remains the most important factor for brain health. The variant alone does not justify specific supplementation or drastic changes. Consult a physician or sports medicine specialist for personalized advice.