To lower triglycerides with exercise, a combination of aerobic and resistance training is most effective. Focus on moderate-to-vigorous intensity and consistency (≥150 min/week). Genetic variants like PPARA rs4253778 (GG) or FADS1 rs174537 may influence fat metabolism, but effect sizes are small and not actionable. Key watchpoints: avoid overtraining, which can raise cortisol and inflammation, potentially worsening triglycerides. Pair exercise with a diet low in refined sugars and saturated fats. If you have cardiovascular conditions or take medications (e.g., statins), consult a doctor before starting. Monitor blood lipids regularly, as individual responses vary. Evidence for exercise benefit is strong; gene–exercise interactions are moderate to weak.
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