What to watch with CYP2D6 and skin aging?

CYP2D6 is a drug-metabolizing enzyme primarily expressed in the liver. There is no strong scientific evidence directly linking CYP2D6 genotype to skin aging. Hypothetical connections involve its role in metabolizing endogenous compounds like melatonin and serotonin, which could theoretically influence oxidative stress or inflammation pathways relevant to skin aging. However, human studies confirming such an effect are lacking, and no validated biomarkers exist to personalize skincare based on CYP2D6. What is well-established: CYP2D6 variants affect the metabolism of many medications (e.g., beta-blockers, antidepressants, opioids). Altered enzyme activity (poor, intermediate, extensive, or ultrarapid metabolizer) can change drug efficacy and side effects, which might indirectly impact skin health. For anti-aging advice, CYP2D6 genotyping is not clinically useful. Focus on proven strategies: sun protection, no smoking, balanced diet, and adequate sleep.