How are IgE and Wechseljahre related?

The relationship between IgE (immunoglobulin E) and menopause is not well established scientifically. IgE is primarily involved in allergic responses, while menopause is characterized by a sharp decline in estrogen and progesterone. Estrogen has immunomodulatory effects, including on IgE production. Some studies suggest that the drop in estrogen during menopause may shift the immune system toward a stronger Th2 response, potentially increasing IgE levels and allergy symptoms. However, findings are inconsistent: some women report worsening, others improvement of allergies. Genetic factors, lifestyle, and comorbidities also play major roles. No direct clinical recommendations for IgE measurement or modulation during menopause can be derived from current evidence. The evidence is mostly mechanistic and based on observational studies. Caveat: Individual variability is high; hormone replacement therapy may influence immune function but should not be used solely for allergy control.