Myths vs facts: Folsäure and Langlebigkeit

Folic acid (vitamin B9) is often marketed as a longevity booster, but the evidence is mixed. It is essential for DNA synthesis and methylation, and deficiency raises homocysteine, a risk factor for cardiovascular disease. Observational studies link lower homocysteine to reduced mortality, yet randomized controlled trials (RCTs) have not shown a clear benefit of folic acid supplementation on overall mortality or lifespan. Some meta-analyses even suggest an increased cancer risk with high doses, especially in individuals with pre‑existing lesions. The idea that folic acid directly extends lifespan is therefore a myth. Maintaining adequate folate levels is important, but supplementing beyond the recommended daily intake is not justified for people without deficiency or specific needs (e.g., pregnancy). Genetic variants like MTHFR C677T affect folate metabolism, but evidence for longevity benefits from high doses is lacking. Bottom line: folic acid is vital for health, not a longevity elixir. Focus on a balanced diet rich in leafy greens and legumes rather than high‑dose supplements.