What role does IgE play in stress?

IgE (immunoglobulin E) is primarily known for its role in allergic reactions and defense against parasites. A link to stress is discussed in research but is not well established. Stress hormones like cortisol can modulate the immune system, and there is some evidence that chronic stress may indirectly influence IgE production—for example, through a shift in the TH1/TH2 balance. However, the effects are small, highly individual, and insufficient for clinical recommendations. Direct-to-consumer tests that connect IgE to stress often rely on weak evidence or marketing. If you measure IgE, it should be in the context of allergies, not as a stress marker. The overall evidence is unclear and mechanistic. For stress assessment, validated questionnaires and cortisol measurements are more appropriate.