What role does CRP Entzündung play in menopause?

CRP (C-reactive protein) is a well-established biomarker of systemic inflammation. During menopause, CRP levels often rise due to declining estrogen, which normally exerts anti-inflammatory effects. This increase reflects a shift toward a pro-inflammatory state. Observational evidence links elevated CRP in postmenopausal women to higher risks of cardiovascular disease, metabolic syndrome, and bone loss. However, CRP is a non-specific marker, and the evidence for a causal role is moderate (human-observational) – no large randomized trials confirm causality. Genetic variants affecting CRP (e.g., in the CRP gene) have small effect sizes and are not clinically actionable on their own. Lifestyle factors (diet, exercise, weight management) have a stronger impact on CRP levels than common genetic variants. Consumer DNA tests like MyBody-X may include CRP-related SNPs, but their predictive value for menopause-related inflammation is limited. A direct blood CRP measurement is more informative. Caveat: Do not base menopause treatment decisions solely on CRP; interpret in full clinical context.