MyBody-X angle on MTHFR Alltag

The MTHFR variant (C677T, rs1801133) is one of the most common genetic polymorphisms affecting folate metabolism. It reduces enzyme activity by about 30–60%, potentially leading to elevated homocysteine levels. In everyday life, elevated homocysteine is considered a risk factor for cardiovascular disease, but the evidence for a direct causal role is mixed. Many individuals with MTHFR variants have normal homocysteine levels. The notion that everyone with a variant needs methylfolate or special supplements is not strongly supported by clinical trials. Instead, a diet rich in green leafy vegetables, legumes, and fortified grains is the first-line approach. A blood test for homocysteine and folate can provide clarity before supplementing. Consumer DNA tests often overstate the implications. The clinical relevance is highly individual and depends on diet, lifestyle, and other genetic factors. Be cautious of marketing claims that portray MTHFR as a 'master' health gene. Evidence: mechanistic and epidemiological, with no robust RCTs supporting routine supplementation in healthy individuals.