Is tTG IgA useful for longevity?

The tTG IgA test is a well-established biomarker for celiac disease, not directly for longevity. Untreated celiac disease can cause chronic inflammation and nutrient malabsorption, which may negatively impact healthspan – an indirect link to longevity is plausible. However, there is no strong evidence supporting tTG IgA as a standalone longevity marker in the general population without celiac suspicion. Its use is only justified when clinical symptoms or family history indicate celiac disease. Routine testing for longevity purposes is not evidence-based. The evidence for benefit in asymptomatic individuals is weak and based on mechanistic reasoning. Caution: a positive result without confirmatory biopsy may cause unnecessary anxiety.