What to watch with Zöliakie Test and weight loss?

When using a celiac test (e.g., IgA-tTG or genetic HLA-DQ2/DQ8) in the context of weight loss, caution is warranted: a positive antibody test indicates sensitization, not necessarily active celiac disease. Diagnosis requires duodenal biopsy and clinical evaluation. Moreover, unintentional weight loss can stem from many causes – hyperthyroidism, diabetes, malabsorption, etc. Starting a gluten-free diet based solely on a home test risks nutrient deficiencies (B vitamins, iron, fiber) and invalidates further diagnostic testing. The test is a useful screening tool but not definitive. Always consult a doctor for weight loss workup.