Evidence check: Zink in the context of Langlebigkeit

The role of zinc in longevity is not yet firmly established by human evidence. Zinc is an essential trace element involved in immune function, DNA repair, and antioxidant defense—all processes linked to aging. Some observational studies associate low zinc status with increased inflammation and shorter telomere length, a proposed biomarker of biological aging. However, randomized controlled trials demonstrating that zinc supplementation extends lifespan in healthy humans are lacking. Most evidence comes from mechanistic studies and animal models. Furthermore, excessive zinc intake (above 25–40 mg/day) can cause copper deficiency and neurological issues. For generally healthy individuals with adequate dietary intake, routine zinc supplementation for longevity is not supported by current science. If a deficiency is suspected (e.g., in older adults or vegans), medical assessment is recommended. Overall, the evidence level is best described as 'mechanistic' to 'unclear'.