Evidence check: Zöliakie Test in the context of longevity

A celiac test (e.g., HLA-DQ2/DQ8 or antibody test) can be relevant in a longevity context because undiagnosed celiac disease may cause chronic inflammation, nutrient malabsorption, and increased mortality. However, the predictive value for asymptomatic individuals is limited: the genetic predisposition (HLA-DQ2/DQ8) is common (~30% of the population), but only ~1% actually develop celiac disease. A positive genetic test alone does not justify a gluten-free diet without clinical confirmation. The evidence for population screening to extend lifespan is moderate – benefits are clearer in symptomatic or high-risk groups. Without a confirmed diagnosis, an unnecessary gluten-free diet can lead to nutritional deficiencies and social burden. Therefore, interpret any test only with medical guidance.