What role does VKORC1 play in Langlebigkeit?

VKORC1 encodes vitamin K epoxide reductase, a key enzyme in the vitamin K cycle. Vitamin K is essential for blood clotting and also supports bone and cardiovascular health, which are relevant to healthy aging. However, direct evidence linking VKORC1 variants to longevity is limited and mostly mechanistic. Most research focuses on warfarin sensitivity, not lifespan. While some studies suggest associations with bone mineral density or vascular calcification, these are not robustly replicated. Consumer DNA tests often overstate such links. A balanced diet rich in vitamin K (e.g., leafy greens) is more impactful than any single VKORC1 variant. Evidence: mechanistic.