What role does CYP1A2 play in Müdigkeit?

CYP1A2 is a liver enzyme responsible for metabolizing caffeine. The rs762551 variant (also called *1F allele) modulates enzyme activity: the A allele confers fast metabolism, while the C allele leads to slower clearance. Slow metabolizers may experience prolonged caffeine effects, potentially disrupting sleep and contributing to fatigue. However, the link between CYP1A2 and fatigue is indirect and context-dependent—caffeine dose, sleep habits, and tolerance play major roles. A DNA test can reveal your genotype, but its predictive value for everyday tiredness is limited. Evidence comes from human observational studies and GWAS, not from controlled trials proving causation. If fatigue is persistent, medical evaluation for iron deficiency, thyroid issues, or sleep disorders is recommended.