How are CYP2D6 and skin aging related?

The relationship between CYP2D6 and skin aging is poorly supported by evidence. CYP2D6 is a cytochrome P450 enzyme primarily involved in drug metabolism, not directly in skin aging processes. Some speculative hypotheses suggest that CYP2D6 variants might affect the metabolism of endogenous compounds like melatonin or estrogens, which could theoretically influence oxidative stress or collagen integrity. However, no robust human studies demonstrate a direct causal link between CYP2D6 polymorphisms and skin aging. Most claims come from nutrigenetic marketing rather than clinical research. Skin aging is predominantly driven by UV exposure, lifestyle factors (smoking, diet), and other well-established genetic markers (e.g., MC1R, collagen-related genes). Consumer DNA tests that include CYP2D6 for skin aging lack strong evidence and should be interpreted with caution. The evidence level is 'mechanistic/unclear' at best.