What to watch with Progesteron and sleep?

Progesterone can promote sleep via its GABA-agonist effects, especially during the luteal phase or with hormone replacement therapy. However, evidence is mixed: some studies show improved sleep quality, while others report morning drowsiness or dizziness. Key considerations: dosage and timing (evening vs. morning) significantly affect outcomes. Interactions with other hormones (e.g., estrogen) or medications (e.g., benzodiazepines) are possible. Bioidentical progesterone appears more sleep-promoting than synthetic progestins. Individual genetic variants in progesterone receptors or GABA metabolism may modulate response, but data are limited. Safety note: Progesterone should only be used under medical supervision, especially for sleep issues. Evidence is primarily mechanistic and observational; large RCTs are lacking.