What to watch with HLA-DQ2 and menopause?

HLA-DQ2 is a genetic risk marker for celiac disease. During menopause, hormonal shifts (declining estrogen) can affect gut permeability and immune responses. In women with HLA-DQ2 and unexplained symptoms (fatigue, joint pain, digestive issues), targeted celiac screening may be considered. However, most HLA-DQ2 carriers never develop celiac disease. A positive genetic test alone does not justify a gluten-free diet without medical evaluation. Additionally, menopause itself can cause overlapping symptoms. Evidence: mechanistic, no direct studies in provided context. Caution against self-diagnosis or unguided dietary changes.