Evidence check: CYP2D6 in the context of skin aging

The link between CYP2D6 and skin aging lacks solid scientific evidence. CYP2D6 is a drug-metabolizing enzyme primarily involved in breaking down medications (e.g., antidepressants, beta-blockers). No robust human studies demonstrate a direct effect on wrinkle formation, collagen degradation, or oxidative skin damage. Some speculative mechanisms (e.g., metabolism of melatonin or serotonin) have been discussed, but the evidence remains extremely weak. Consumer DNA tests that associate CYP2D6 with skin aging typically rely on exaggerated marketing claims. The actual relevance for skin health is negligible. Established factors like UV protection, diet, smoking, and genetic variants in collagen/elastin genes (e.g., COL1A1) are far more important. If you still purchase the test, do not interpret CYP2D6 results as a skin aging marker. Avoid unnecessary supplements or treatments based on this. Evidence: mechanistic/speculative.