Evidence check: LCT in the context of skin aging

The link between the LCT gene (lactase) and skin aging is not scientifically established. LCT determines lactose digestion capacity; variants like LCT-13910 C/T are associated with lactose intolerance. Some hypothetical mechanisms have been proposed: lactose intolerance might indirectly affect skin aging via systemic inflammation or altered gut microbiota, but no direct human studies support this. Evidence is purely mechanistic/speculative. Skin aging is primarily driven by UV exposure, oxidative stress, collagen degradation, and lifestyle factors. Genetic testing for LCT variants is not useful for assessing skin aging risk. Consult a dermatologist for skin concerns.