Can FADS1 help with Haut?

FADS1 encodes delta-5 and delta-6 desaturases, key enzymes in omega-3 and omega-6 fatty acid metabolism. Genetic variants (e.g., rs174547) have been linked to altered fatty acid profiles and, in some studies, to skin conditions like atopic dermatitis, eczema, and dry skin. The mechanism is plausible: imbalances in pro- and anti-inflammatory lipid mediators affect skin barrier function and immune responses. However, the effect size is modest, and diet (e.g., intake of EPA/DHA or linoleic acid) strongly modifies the outcome. A DNA test can indicate genetic predisposition, but it does not predict or guarantee skin improvement. Evidence is based on GWAS and mechanistic studies, not on clinical trials testing direct supplementation based on genotype. Therefore, FADS1 is one factor among many; optimizing skin health requires a holistic approach including nutrition, skincare, and lifestyle.