Myths vs facts: Progesteron and Allergie

The claim that progesterone can influence allergies is not unfounded, but the evidence is limited and contradictory. Mechanistically, progesterone modulates the immune system by promoting a Th2-shifted response, which could theoretically exacerbate allergic reactions. Conversely, observational studies suggest that high progesterone levels during pregnancy may alleviate certain allergies, possibly due to general immunosuppression. However, randomized controlled trials on targeted progesterone therapy for allergies are largely absent. MyBody-X tests on hormones and allergies rely on such mechanistic and epidemiological data, not on clinical practice. A direct causal effect is not established. Moreover, individual responses depend heavily on genetics, environment, and lifestyle. Bottom line: plausible mechanisms exist, but evidence is insufficient for a recommendation. Those with allergies should not rely on progesterone self-tests but seek medical evaluation.