What role does APOA2 play in Sport?

APOA2 encodes apolipoprotein A-II, a component of HDL cholesterol. In the context of sport, there is no direct, robust evidence for a performance-relevant function. Some association studies (e.g., rs5082) suggest links to BMI and dietary fat intake, which could indirectly affect weight management in athletes. However, intervention studies demonstrating a causal role of APOA2 variants on endurance, strength, or recovery are lacking. The evidence is therefore weak to mixed. Genetic testing for APOA2 polymorphisms to optimize sports performance is currently not scientifically supported and should not be used as a basis for training or nutrition decisions.