For an MTHFR genetic test (e.g., saliva sample), no special preparation is required – you do not need to fast, stop medications, or avoid certain foods. The test analyzes DNA for variants in the MTHFR gene (C677T and A1298C), which affect folate metabolism. However, the clinical impact of these variants is small and often overestimated. A positive result does not indicate a disease; it merely suggests a possible need for adjusted folate intake. Do not change any supplements (e.g., folic acid or methylfolate) before testing – discuss results with a healthcare professional. The test is intended for adults; for minors, medical supervision is recommended. Evidence is mostly marketing-based, as the relevance of MTHFR variants in routine health is debated. Do not base treatment decisions solely on this test.
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