Skincare DNA tests typically analyze single SNPs linked to collagen (e.g., COL1A1), antioxidant defense (e.g., SOD2), or UV sensitivity (e.g., MC1R). However, effect sizes are small – lifestyle factors (sun exposure, diet, smoking) account for >80 % of skin aging. Current polygenic risk scores for skin traits lack clinical utility. Commercial tests often overstate their predictive power. A potential benefit is motivating better sun protection or skincare habits, but personalized product recommendations are not evidence-based. Caution: MC1R variants do increase melanoma risk, but this is already indicated by skin type. Overall: evidence weak, marketing strong. Not a medical diagnosis; limited practical value.
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